Endocrine Abstracts

A 41-year-old female was diagnosed with generalised seizures in 1984 and her EEG showed excess slow wave activity in the temporal region. She was commenced on carbamazepine. In 2005 she was diagnosed to have a bipolar affective disorder for which olanzapine was added.She was found to be hypocalcaemic with corrected calcium of 2.08 mmol/l in 2005 after sustaining a right undisplaced distal radial fracture following a seizure. She was empirically commenced...

Introduction: Prostate cancer (PC) is dependent on androgen receptor (AR) activation by its canonical ligands testosterone and 5α-dihydrotestosterone (DHT). Intratumoural androgens persisting after castration give rise to castration-resistant PC (CRPC). These intraprostatic androgen levels are hypothesized to result from either adrenal androgen conversion or intratumoural de novo DHT synthesis through the classic or alternative pathways. Quantifying the steroid f...

Background: Glucocorticoids play a key role in determining body fat distribution. Excess circulating glucocorticoids lead to intrahepatic fat accumulation. Obesity is associated with enhanced glucocorticoid production but this is offset by enhanced degradation such that circulating steroid concentrations are normal. However, tissue-specific pathways may lead to different degrees of cortisol exposure in different organs. Local steroid exposure in the liver is determined by the ...